CIT Rapid Test Dipstick Citalopram Test Kit For Desmethylcitalopram
Brand Name:Citest
Certification:CE
Model Number:DCIT-101/111
Minimum Order Quantity:N/A
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CIT Rapid Test Dipstick(Urine), Citalopram Test Kit. Detection Of
Desmethylcitalopram
CIT Rapid Test Dipstick (Urine), Citalopram Test Kit. detection of
Desmethylcitalopram
| Product Name: | CIT Rapid Test Dipstick(Urine), Citalopram Test Kit. Detection Of Desmethylcitalopram |
| Brand: | Citest |
| Format: | Cassette |
| Certificate: | CE |
| Pack: | 50T |
| Shelf Life: | 2 Years |
| Specificity: | 95.50% |
| Cut-Off: | 500 Ng/mL |
| CAT NO.: | DCIT-111/101 |
| Principle: | Chromatographic Immunoassay |
| Specimen: | Urine |
| Reading Time: | 5 Minutes |
| Storage Temperature: | 2-30°C |
| Sensitivity: | 93.30% |
| Accuracy: | 94.80% |
| PRODUCT FEATURES: | High Accuracy |
Application
The CIT Rapid Test Dipstick (Urine) is a rapid chromatographic
immunoassay for the detection of Desmethylcitalopram in urine at a
cut-off concentration of 500ng/ml. This test will detect other
related compounds, please refer to the Analytical Specificity table
in this package insert.
This assay provides only a qualitative, preliminary analytical test
result. A more specific alternate chemical method must be used in
order to obtain a confirmed analytical result. Gas
chromatography/mass spectrometry (GC/MS) is the preferred
confirmatory method. Clinical consideration and professional
judgment should be applied to any drug of abuse test result,
particularly when preliminary positive results are used.
SUMMARY
Citalopram, an antidepressant of the selective serotonin reuptake
inhibitor (SSRI) type, is only available as a racemic drug. Its
metabolism occurs, partially, by N-demethylation to
demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT), but
also by deamination to a propionic acid derivative (CIT-PROP) and
by N-oxidation to CIT-N-oxide (NO-CIT) [1]. CIT has equal affinity
for 5-HTT and dopamine transporters [2] . Studies have shown that
compared with healthy subjects, the binding potential of thalamus
and brainstem binding area in patients with depression who take
20-60 mg citalopram every day is reduced by 50% [3] .
It is supplied as the free base in 20 mg tablets oral
administration; daily oral dose for adults usually range from 20-60
mg. The common adverse reactions were nausea, dry mouth and
drowsiness. The rare adverse reactions were agitation, income and
anxiety. The oral bioavailability of citalopram is about 80%.15% of
citalopram is excreted by kidney, and 12%-23% of citalopram in
daily dose is excreted in original form from urine.
PRINCIPLE
The CIT Rapid Test Dipstick (Urine) is an immunoassay based on the
principle of competitive binding. Drugs which may be present in the
urine specimen compete against the drug conjugate for binding sites
on the antibody. During testing, a urine specimen migrates upward
by capillary action. Desmethylcitalopram, if present in the urine
specimen below the cut-off level, will not saturate the binding
sites of the antibody in the test. The antibody coated particles
will then be captured by immobilized Citalopram-protein conjugate
and a visible colored line will show up in the test line region.
The colored line will not form in the test line region if the
Desmethylcitalopram level exceeds the cut-off level, because it
will saturate all the binding sites of anti-citalopram antibody.
A drug-positive urine specimen will not generate a colored line in
the test line region because of drug competition, while a
drug-negative urine specimen or a specimen containing a drug
concentration less than the cut-off will generate a line in the
test line region. To serve as a procedural control, a colored line
will always appear at the control line region indicating that
proper volume of specimen has been added and membrane wicking has
occurred.
DIRECTIONS FOR USE
Allow the test, urine specimen, and/or controls to reach room
temperature (15-30°C) prior to testing.
1. Bring the pouch to room temperature before opening it. Remove
the test card from the sealed pouch and use it within one hour.
2. With the arrow pointing toward the urine specimen, immerse the
test dipstick vertically in the urine specimen in such a way that
urine does not cross MAX line on the test Dipstick for 10-15
seconds. See the illustration below.
3. Place the Test Dipstick on a non-absorbent flat surface, start
the timer and wait for the colored line(s) to appear. Read results
at 5 minutes. Do not interpret the result after 10 minutes.
INTERPRETATION OF RESULTS
(Please refer to the illustration above)
NEGATIVE:* Two colored lines appear. One colored line should be in
the control line region (C), and another apparent colored line
should be in the test line region (T). This negative result
indicates that the Desmethylcitalopram concentration is below the
detectable cut-off level.
*NOTE: The shade of color in the test line region (T) may vary, but
it should be considered negative whenever there is even a faint
colored line.
POSITIVE: One colored line appears in the control line region (C).
No line appears in the test line region (T). This positive result
indicates that the Desmethylcitalopram concentration exceeds the
detectable cut-off level.
INVALID: Control line fails to appear. Insufficient specimen volume
or incorrect procedural techniques are the most likely reasons for
control line failure. Review the procedure and repeat the test with
a new test. If the problem persists, discontinue using the test kit
immediately and contact your local distributor.
Order Information
| Cat. No. | Product | Specimen | Pack |
| DCIT-102 | CIT Rapid Test Cassette | Urine | 25T |
| DCIT-114 | CIT Rapid Test Panel | Urine | 25/40T |
| DCIT-101/111 | CIT Rapid Test Dipstick | Urine | 50T |
CIT Rapid Test Dipstick Citalopram Test Kit For Desmethylcitalopram
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