Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery

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Guaifenesin Basic information
Description References
Product Name:Guaifenesin
Synonyms:1,2-Dihydroxy-3-(2-phenoxy)propane;1,2-Propanediol, 3-(2-phenoxy)-;1,2-Propanediol, 3-(o-phenoxy)-;2/G;2-G;3-(2-phenosy)-1,2-propamediol;3-(2-phenoxy)-2-propanediol;3-(o-phenoxy)-2-propanediol
CAS:93-14-1
MF:C10H14O4
MW:198.22
EINECS:202-222-5
Product Categories:Building Blocks;C10;Chemical Synthesis;rs;Organic Building Blocks;Oxygen Compounds;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Methocarbamol;API;MUCINEX;Benzhydrols, Benzyl & Special Alcohols
Mol File:93-14-1.mol
Guaifenesin Chemical Properties
Melting point77-81 °C
Boiling point215 °C (19 mmHg)
density1.1825 (rough estimate)
refractive index1.5550 (estimate)
Fp215°C/19mm
storage temp.Refrigerator
solubility50g/l (experimental)
formneat
pka13.53±0.20(Predicted)
Water Solubility5 g/100 mL (25 ºC)
Merck14,4555
BRN2049375
InChIKeyHSRJKNPTNIJEKV-UHFFFAOYSA-N
CAS DataBase Reference93-14-1(CAS DataBase Reference)
NIST Chemistry Reference3-(O-phenoxy)-1,2-propanediol(93-14-1)
EPA Substance Registry SystemGuaifenesin (93-14-1)
Safety Information
Hazard CodesXn
Risk Statements22-36/37/38
Safety Statements26-36
WGK Germany1
RTECSTY8400000
Hazard NoteHarmful
TSCAYes
HS Code29093090
Hazardous Substances Data93-14-1(Hazardous Substances Data)
ToxicityLD50 oral in rabbit: 2553mg/kg
MSDS Information
ProviderLanguage
ACROSEnglish
SigmaAldrichEnglish
ALFAEnglish
Guaifenesin Usage And Synthesis
DescriptionGuaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections.
References[1] Peter V. Dicpinigaitis and Yvonne E. Gayle, Effect of Guaifenesin on Cough Reflex Sensitivity, 2003, vol. 124, 2178-2181
[2] Leonid Kagan, Eran Lavy and Ammon Hoffmann, Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model, Pulmonary Pharmacology & Therapeutics, 2009, vol. 22, 260-265
Chemical PropertiesWhite Solid
OriginatorGG Cen,Central,US,1975
UsesCentrally acting muscle relaxant with expectorant properties
UsesUsed to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Manufacturing ProcessA mixture of o-phenol (57 g), glycidol (32 g) and pyridine (1 g) is warmed to 95°C at which temperature a vigorous reaction takes place. The reaction mixture is cooled to prevent the temperature rising above 110°C. When the exothermic reaction has subsided the reactants are heated at 95°C for one hour longer and then distilled under low pressure. The main fraction boils in the range 176°C to 180°C/0.5 mm. It crystallizes on cooling. Recrystallization from benzene gives the pure product, MP 78.5°C to 79.0°C.
Brand nameMucinex (Adams).
Therapeutic FunctionExpectorant
Mechanism of actionGuaiphenesin facilitates secretion from bronchial mucous membranes, thus relieving a cough in colds, bronchitis, and bronchial asthma.
Chemical SynthesisGuaiphenesin, 3-(o-phenoxy)-1,2-propandiol (23.2.3), is synthesized by reacting guiacol with 3-chloropropan-1,2-diol or with glycidol.

Veterinary Drugs and TreatmentsIn veterinary medicine, guaifenesin is used to induce muscle relaxation and restraint as an adjunct to anesthesia for short procedures (30 – 60 minutes) in large and small animal species. There are combination oral products containing guaifenesin for treating respiratory conditions in horses.
In human medicine, guaifenesin has long been touted as an oral expectorant, but definitive proof of its efficacy is lacking.
Guaifenesin Preparation Products And Raw materials
Raw materialsAmmonium hydroxide-->Diethyl carbonate-->Guaiacol-->3-Chloro-1,2-propanediol-->Glycidol
Preparation ProductsZinc oxide-->Lithopone-->Zinc nitrate hexahydrate-->Methocarbamol
China Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery supplier

Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery

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