Pharmar Intermediates N-Methyl-D-aspartic Acid / DMDA CAS No.:
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CAS No.: 6384-92-5
Details of N-Methyl-D-aspartic acid
Superlist Name:N-Methyl-D-aspartic acid(NMDA)
CAS No.: 6384-92-5
Synonyms:(R)-2-(Methylamino)succinic acid; NMDA
N-Methyl-D-Aspartic acid (NMDA) is a water-soluble synthetic
substance that is not normally found in biological tissue. It was
first synthesized in 1960s. N-Methyl-D-Aspartic acid (NMDA) is an
excitotoxin(it kills nerve cells by over-exciting them); this trait
has applications in behavioral neuroscience research. The body of
work utilizing this technique falls under the term "lesion
Researchers apply N-Methyl-D-Aspartic acid (NMDA) to specific
regions of an (animal) subject's brain or spinal cord and
subsequently test for the behavior of interest, such as operant
behavior. If the behavior is compromised, itsuggests the destroyed
tissue was part of a brain region that made an important
contribution to the normal expression of that behavior.
However, in lower quantities N-Methyl-D-Aspartic acid (NMDA) is not
In fact, normal operation of the N-Methyl-D-Aspartic acid (NMDA)
receptor allows individuals to respond to excitatory stimuli
through the interrelated functioning of N-Methyl-D-Aspartic acid
(NMDA) receptors, glutamate, and dopamine.
Therefore the action of glutamate specifically through
N-Methyl-D-Aspartic acid (NMDA) receptors can be investigated by
injecting small quantities of N-Methyl-D-Aspartic acid (NMDA) into
a certain region in the brain: for example, injection of
N-Methyl-D-Aspartic acid (NMDA) in a brainstem region induces
involuntarylocomotion in cats and rats.
The mechanism of stimulating N-Methyl-D-Aspartic acid (NMDA)
receptor is a specific agonist-binding to its NR2 subunits, and
then a non-specific cation channel is opened, which can allow the
passage of Ca2+ and Na+ into the cell and K+ out of the cell. The
excitatory postsynaptic potential (EPSP) produced by activation of
an N-Methyl-D-Aspartic acid (NMDA) receptor also increases the
concentration of Ca2+ in the cell. The Ca2+ can in turn function as
a second messenger in various signaling pathways.This process is
modulated by a number of endogenous and exogenous compounds and
play a key role in a wide range of physiological (e.g. memory) and
pathological processes (e.g. excitotoxicity).
It has been deemed responsible for the incredible increase of
hormonal output experienced during puberty, which results in rapid
muscular and sexual development. This hormonal state is most
desirable for building muscle mass and even useful in enhancing
every aspect of sexual performance. This newly found receptor, when
powerfully activated by amino acid based ingredient called
N-Methyl-D-Aspartic acid (NMDA), elicits profound elevations of
circulating anabolic hormones.There are studies showing it
increases LH and test levels. N-Methyl-D-Aspartic acid (NMDA)
receptor activation also plays a role in developing many
neuro-degerative disorder like Parkinsons.
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