GW 501516 Cardarine White Fat Loss SARM Steroids Powder Cardarine
CAS 317318-70-0 Supplier
GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARd
modulator. GW 501516 activates AMP-activated protein kinase and
stimulates glucose uptake in skeletal muscle tissue, and GW 501516
has been demonstrated to reverse metabolic abnormalities in obese
men with pre-diabetic metabolic syndrome, most likely by
stimulating fatty acid oxidation. It has been proposed as a
potential treatment for obesity and related conditions, especially
when used in conjunction with a synergistic compound AICAR, as the
combination has been shown to significantly increase exercise
endurance in animal studies. GW-50156 regulates fat burning through
a number of widespread mechanisms; it increases glucose uptake in
skeletal muscle tissue and increases muscle gene expression,
especially genes involved in preferential lipid utilization. This
shift changes the body’s metabolism to favor burning fat for energy
instead of carbohydrates or muscle protein, potentially allowing
clinical application for obese patients to lose fat effectively
without experiencing muscle catabolism or the effects and satiety
issues associated with low blood sugar. GW-501516 also increases
muscle mass, which improved glucose tolerance and reduced fat mass
accumulation even in mice fed a very high fat diet, suggesting that
GW-501516 may have a protective effect against obesity.
Effects on Muscle Fibers
The 2015 study by Wei Chen, PhD and his colleges has also found
that dramatic increases in the PPAR gene in slow twitch muscle
fibers increases oxygen usage and greatly increases endurance. The
enhanced endurance was seen in lab mice with a normal oxygen supply
and those with oxygen restrictions which provided significant
evidence that GW501516 targets and enhances skeletal muscle
endurance and recovery time to a supraphysiological level.
A study titled “A metabolomic study of the PPARδ agonist GW501516
for enhancing running endurance in Kunming mice” stated that BCAA
were spared during trials of intense exercise which allowed the
mice to have a greater rate of recovery in muscle tissue and
These rats had even lost weight while maintaining a high fat diet,
suggesting it could potentially prevent obesity and help manage
weight regardless of eatings habits.
Recommendations & Dosing Guidelines for Cardarine
10-20 mg per day is a sufficient dose. It is recommended to start
at 10mg per day to take advantage of the host’s sensitivity to the
new chemical. 10 mg a day is aimed for endurance, and the higher
the dosage the greater the fat loss benefits are going to be
Lab mice should be given dosages 45 minutes- 1 hour before
GW501516 has been tested for a 2 year study and has found no
decreases or stagnation in effects. Most individuals run cycles for
12-14 weeks at a time with a 4-6 week break. This is normally to
coincide with a SARM cycle, but there is no evidence showing that
GW 501516 needs to be off-cycled after such a short amount of time.
GW501516 was created for LONG TERM usage, so there is no reason why
it shouldn’t be used that way.
Half life is between 16-24 hours and should be take at 10mg once a
day or 10mg once every 10-12 hours if taken at a higher dose.
No PCT is needed, GW is recommended in combination with PCT if
highly toxic anabolics have been used.
Highly recommended to use with a ketogenic diet.
Can be used in conjunction with anabolics and stimulants of any
kind without adverse reactions.
How GW 501516 Works
GW stimulates glucose uptake and skeletal muscle tissue. It burns
fat by stimulating fatty acid oxidation. It’s suggested as a
potential treatment for obesity because of it’s ability to rapidly
melt fat. Also, Cardarine is said to increase HDL by an average of
79% (good cholesterol) and decrease LDL (bad cholesterol) in
current Phase II trials. GW 501516 is a PPARδ agonist. These help
increase your HDL levels from an enhanced expression of the
cholesterol transporter ABCA1.
The Side Effects of GW 501516
Not to say that there are none, but in the last 20 years no side
effects have been seen by anyone studying the drug.
GW501516 has not only been tested in healthy subjects, but also
those with simulated “real life” habits (such as drinking alcohol,
stimulant narcotics, and the use of tobacco products). It is
uncertain if there are long term ramifications, but no research has
been published stating otherwise.
This is what makes Cardarine so incredibly popular and usable over
long periods of time. In certain studies, there have even been
signs showing the reversal of diabetes, obesity, Dyslipidemia and
many other diseases.
GW 501516 & Liver Damage
In contrast to popular belief, GW501516 doesn’t promote damage of
liver cells. The chemical has actually been known to promote
healthy liver function and faster healing properties to the skin
and muscle tissue. In essence, you will not heal rapidly like
Wolverine from the X Men movies, but you will shorten the your
recovery time from scratches, blisters, and injured muscles by a
GW 501516 & Cancer
There has been many forum comments expressing the concerns of
GW501516 and it’s relationship to cancer and tumor development. The
hypothesis for this controversy stems from GW’s ability to improve
angiogenesis in the body at an extremely high rate and the rate of
cancer growth in the colons of lab mice. Angiogenesis refers to the
bodies ability to increase blood supply to feed the cells
throughout the body.
This is a common occurrence among endurance athletes and children
going through adolescence. Scientist had speculation that if there
were tumor cells active in the body, that they would be especially
susceptible to angiogenesis and cause the tumor to grow at a much
faster rate. Since 2004 many experiments have been done to prove
this hypothesis, but so far, all of them have been largely
A study published in 2004 by the American Association of Cancer
Research stated that PPAR agonists have
“…shown to have no effect on the proliferation of colorectal cancer
cells” and “…under normal culture conditions, PPAR activation has
no effect on cell growth”.
Keep in mind that this study was done in rats given amounts of 400
mg a day and was abused and ran for hundreds of weeks to top it all
off. Time and time again this study has been refuted and shown to
be deeply flawed and inaccurate.
In a 2008 experiment done on human breast cancer and colon cancer
cells, not only did the PPAR agonist GW 501516 prove to be safe for
use, it has proven to inhibit cancer cell growth. The National
Institute of Health has confirmed without a reasonable doubt that
GW 501516 inhibits a multitude of cancers in human cells.
Over a decade of research studies on human PPAR beta (the primary
target of GW) has only proven a decrease in cancer cells with
extended use (up to two years). The confusion for these previous
allegations of cancer growth were from results published in 1996
and have long since been abandoned due to new clinical research.
The chemical compound has been dosed in human PPAR for a number of
years and has only provided positive results on cancer treatments,
liver function, and metabolic efficiency.
In all of the human studies done so far, there were no noticeable
side effects at all while running GW.
Stacking GW 501516
Stacking Cardarine means running it in combination with other
compounds. What makes Cardarine stand out is it can be used with
almost anything (cutting, bulking or recomping).
Bulking - clean up your gains and make that bulk cleaner while
Cutting - totally optimal when it comes to weight loss while
holding on to muscle mass.
Recomping - perfect for building lean muscle and losing fat
The most common way to use Cardarine is in a triple stack involving
LGD 4033 and MK 2866. You’ll have all the gains, endurance, fat
loss and size gains by taking all three.
BUY most popular SARMs, Selective Androgen Receptor Modulators:
-Increase lean muscle mass
-Increase bone density
-Can be taken orally
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