Galantamine CAS 357-70-0 Pharmaceutical Raw Materials Nootropics
Galanthamine,White or slightly yellow crystalline powder. Odorless,
bitter taste. Melting point 127 ~ 129 ºC, [α] D20-118.8 °
(ethanol). Soluble in ethanol, acetone, chloroform, insoluble in
benzene, ether and water. After reaction with ammonium molybdate
solution, water bath, evaporate, sulfuric acid is added ,it turns
Use bulbs of Lycoris squamigera Maxim as raw material, under
different acidity , extract and refine repeatedly with ethanol and
chloroform to obtain the product . It belongs to
anti-cholinesterase drugs.It is used for sequelae of infantile
paralysis and myasthenia gravis. Medicinal use is its hydrobromide.
1. Galanthamine is alkaloid which is extracted from Amaryllidaceae
plants Lycoris squamigera Maxim or Lycoris aurea,it is a reversible
anti-cholinesterase drug, it is easy for it to go through the blood
brain barrier into the brain tissue ,its effect on central nervous
system is stronger.
2. it can improve neuromuscular conduction , compared with
physostigmine, neostigmine , pyridostigmine , it has wide range of
treatment, and low toxicity, muscarinic effects are weak and
short-lived. Clinically Galanthamine is used not only for the
treatment of myasthenia gravis, polio sequelae resting, but also
for children with cerebral palsy, multiple neuritis, radiculitis
and sensorimotor disorders caused by nervous system disease or
Application and Dosage
1. Galanthamine hydrobromide is used for myasthenia gravis,
muscular dystrophy, polio sequelae, children cerebral palsy,
sensory or motor disorders caused by neurological disorders ,
2.The oral dosage form of the drug can be used for memory
impairment, mild to moderate Alzheimer's disease.
Oral: it is used for myasthenia gravis, muscular dystrophy,
multiple peripheral neuropathy treatment: 1 10mg per time, tid.
Children 0.5 ~ 1mg / (kg · d), 3 times.
3. It is used for Alzheimer's disease: initial dose of 1 4mg, bid,
for four weeks; maintenance dose of 8mg per time, bid, at least for
four weeks; maximum maintenance dose of 1 times 12mg, bid.
Intramuscular or subcutaneous injection: 2.5 ~ 10mg / d, children
each 0.05 ~ 0.1mg / kg, qd, 1 course is 2 to 6 weeks. Poliomyelitis
continuous medication 40 ~ 50d, the general course of treatment is
20 ~ 40d, the start of the second compartment is 30 ~ 45d after
treatment. After 1 to 2 courses ,if the condition has not been
improved, patients should stop the medication. If it is effective
,3 courses can be used. Application of the dose should be small to
large, in order to reduce adverse reactions.
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Adrafinil is easily available from supplement shops in the USA
while Modafinil requires a prescription. That’s to say, adrafinil,
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The side effects of Modafinil are similar to those listed for
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enzymes present actually convert this drug into Modafinil. It is
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Consequently, Modafinil may be safer than Adrafinil in the long
3. Potency and speed
Adrafinil is first metabolized into modafinil in the liver.
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before eating anything. Because of the additional processing,
Adrafinil takes longer time to take effect than Modafinil.
Aniracetam is a Nootropic supplement which was developed in the
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