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Animal Extracts Pharmaceutical Raw Powder Tauroursodeoxycholic Acid / TUDCA CAS 14605-22-2 For Liver Disorder

Animal Extracts Pharmaceutical Raw Powder Tauroursodeoxycholic Acid / TUDCA CAS 14605-22-2 For Liver Disorder

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Animal Extracts Pharmaceutical Raw Powder Tauroursodeoxycholic Acid / TUDCA CAS 14605-22-2 For Liver Disorder


TAUROURSODEOXYCHOLIC ACID


CAS:14605-22-2

MF:C26H45NO6S

MW:499.7

Synonyms:3ALPHA,7BETA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-(2-SULFOETHYL)AMIDE;TAUROURSODEOXYCHOLIC ACID;TAUROURSODESOXYCHOLIC ACID;2-(((3-alpha,5-beta,7-beta)-3,7-dihydroxy-24-oxocholan-24-ethanesulfonicaci ;2-(((3-alpha,5-beta,7-beta)-3,7-dihydroxy-24-oxocholan-24-yl)amino)ethanesul ;fonicacid ;n-(3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oyl)-taurin ;ur906

Properties

Melting point:173-175°C

refractive index 46 ° (C=1, EtOH)

storage temp. +15C to +30C

InChIKeyBHTRKEVKTKCXOH-LBSADWJPSA-N


Abstract


Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears.


TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding

TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's Disease, and stroke.Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.


Application


TUDCA has significant protective properties for many organs throughout the human body.It protects skeletal muscles and other organs, particularly the liver, by increasing insulin sensitivity to appropriate levels.TUDCA has shown to do this by protecting endoplasm reticulum from stress.

Insulin resistance plays a large part in health issues related to excess fat.TUDCA is used for many liver healing and immune-improving purposes, and also is used to support a healthy gallbladder.

This dietary supplement may have some powerful neuroprotective properties, and is indicated in the protection of cells from destruction.To protect cells, TUDCA modulates certain cell cycle effector genes.While these signaling pathways have been identified, the full role of TUDCA in cell maintenance is not yet fully understood.

By protecting cells from destruction, TUDCA has proven to be effective in helping eye's maintain cones and rods.This photoreceptor protection can go a long way in promoting healthy vision. TUDCA is also linked to increased antioxidant activity.


Specification


AppearanceWhite or off-white crystalline powderWhite crystalline powder
SolubilityFreely soluble in Methanol
and ethanol.
Sparingly soluble in water.
Practically insoluble in ethyl
acetate and acetone.
Conforms
Specific optical rotation+45.0° ~ +47.0°+46.1°
Water6.0%~8.0%7.1%
Sulphate Ash≤0.1 %0.04 %
Related substances(TLC)
Taurine≤ 0.2%Not detected
Ursodeoxycholic Acid≤ 0.5%< 0.5%
Total unspecified impurities≤ 0.5%Not detected
Related substances
Taurochenodeoxycholic Acid≤ 1.0%0.02%
Any other impurity≤ 0.1 %0.04%
Total unspecified impurities≤ 0.5%0.05%
Heavy metal≤ 20 ppm< 20ppm
Residual solvents
Acetone≤ 5000ppm2.9 ppm
Ethyl acetate≤ 5000ppmNot detected
Microbiological Test
Total plate count≤ 1000 CFU/g<10 CFU/g
Yeast and mold≤ 100 CFU/g<10 CFU/g

Liver Care

To the steroid user, the incorporation of TUDCA into any cycle regimen is key to help guard your body from bad side-effects. Over time, someone who has been using a moderate amount of oral steroids can put a serious strain on their liver. As the steroids pass through the liver and metabolize, they cause cell damage. The damage to liver cells by steroids can lead to jaundice and serious liver disease. In addition, steroids can directly inhibit the production and flow of bile from the liver, this is known as cholestasis. TUDCA has been used to help the bile flow (fix cholestasis) and help cleanse out the liver.

Tauroursodeoxycholic acid (TUDCA) is a liver aid introduced as a supplement by ThermoLife in their product Liver Longer. It looks like a good resource for preventing cholestasis, one of the major risks with 17 alkylated steroids.

Tauroursodeoxycholic acid is an anti-cholestatic agent, modulating protein kinase C (PKC) pathway. PKC reduces ischemic damage in several organs. Its isoform modulates ezrin, a key protein in the maintenance of cell lamellipoidal extensions.

TUDCA, a metabolite to UDCA (Ursodeoxycholic acid), is basically a particular Bile Acid enzyme that is naturally produced in the Liver. TUDCA has been proven in over 220 documented cases to dramatically improve both the performance of the liver as well as decrease pre-existing damage. TUDCA (Liver Longer) reduces the enzymatic stress on the liver.


Steroid PCT Use

TUDCA isn't just for use during steroid cycles. It should also be used in post cycle therapy (PCT). When you run a steroid cycle, your heart and liver are sure to become strained. Continuing to cleanse your body during post-cycle therapy, when you are off the steroids, can help you release the built up toxins. This should help you feel better and return to your health levels before the cycle started. Those that blast and cruise (BnC) can also take advantage of TUDCA, as it cleanses the liver rather effectively even during BnC runs. In simple terms, it means more blasting and less cruising.

The advantage of using TUDCA over other support supplements, such as milk thistle, is that milk thistle will only help your liver, but TUDCA will do so much more to help your overall bile mobilization. For this reason, TUDCA blows away any other cycle support supplement.


Diabetes And Weight Loss

Studies have shown that TUDCA also helps with blood glucose and insulin which explains why it has become popular among the diabetic groups. In fact, another study showed it aided fat loss and helped neutralize weight in both men and women. So in other words, if you are overweight it will aid in weight loss and if you are underweight it can help you gain some lean mass.



Dose


Recommended dosage, active amounts, other details 10-13mg daily has once been shown to improve liver regenesis rates in a clinically ill population, and may be the lowest estimate of an active oral dose. When looking at improving bile salt composition, a dose around 15-20mg/kg bodyweight TUDCA seems best according to one study.Benefits have been seen at 1,750mg daily for muscle and liver insulin sensitivity, which is the highest dose used for treatment of fatty liver disease.


Nootropic-Brain health
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1SunifiramCAS: 314728-85-3
2PirespaCAS: 53179-13-8
3AdrafinilsCAS: 63547-13-7
4ColuracetamCAS: 135463-81-9
5NoopeptCAS: 157115-85-0
6UnifiramCAS: 272786-64-8
7PiracetamCAS:7491-74-9
8IdebenoneCAS:58186-27-9
9phenylpiracetamCAS:77472-70-9
10PramiracetamCAS:68497-62-1
11RivastigmineCAS:123441-03-2
12EntacaponeCAS:130929-57-6
13OxiracetamCAS:62613-82-5
14AniracetamCAS:72432-10-1
15DonepezilCAS:120014-06-4
16brivaracetamCAS:357336-20-0
17EtiracetamCAS:33996-58-6
18RaubasineCAS:483-04-5
19Rivastigmine tartrateCAS:129101-54-8
21Alpha GPCCAS:28319-77-9
22CDP CiticolineCAS:987-78-0
23CRL-40,941(Fladrafinil)CAS:90212-80-9
24FasoracetamCAS:110958-19-5
25GalantamineCAS:1953-04-4
269-fluorenolCAS:1689-64-1
27Huperzine ACAS:102518-79-6
28NSI-189 free baseCAS:1270138-40-3
29NSI-189 phosphateCAS:1270138-41-4
30PhenibutCAS:1078-21-3
31PicamilonCAS:62936-56-5
32PRL-8-53CAS:51352-87-5
33Tianptine sodiumCAS:30123-17-2
34VinpocetineCAS:42971-09-5
35VincamineCAS:1617-90-9
36TheacrineCAS:2309-49-1

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