SARMs Steroid Raw Powder GW 501516 / Cardarine CAS 317318-70-0 For
Product Name: Gw-501516
Other Name: Cardarine; Free Acid; GSK-516
Model NO.: 317318-70-0
Suitable for: Adult
Molecular Formula: C21h18f3no3s2
Melting Point: 134-136ºC
Appearance: White Powder.
State: Powders, Solid
Molecular Weight: 453.5
|Product Name||GW-501516 / Cardarine|
acid;GW501516, Free Acid;GSK-516|
|Product Categories||Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur &
androgen receptor modulator)|
|Usage||1, It had been investigated as a potential treatment for obesity,
diabetes, dyslipidemia and cardiovascular disease.|
2, GW501516 could be used by athletes and bodybuilders as an
ergogenic performance enhancing drug.
GW-501516 is a unique medication officially classified as a PPAR
receptor agonist (PPAR-RA). Research for this medication began in
1992 in a conjoined effort between GlaxoSmithKline (GSK) and Ligand
Pharmaceuticals. Research into this product was set forth in an
effort to provide treatment for various cardiovascular diseases, as
well as diabetes, obesity and other conditions. It was soon
discovered that the PPAR-RA was highly effective at enhancing
endurance, but it was also shown to carry a high potential cost. It
was discovered that GW-501516 increased the chances of cancer
significantly, and as a result, GSK dropped all further research.
However, the studies that produced cancerous results used doses of
GW-501516 that were 500 to even 1000 times the amount that a human
being would take. If cancer is a risk with standard dosing is
GW-501516 binds to the PPAR receptor, specifically a group of
nuclear receptors (sensors that detect thyroid and steroidal
hormones in the body) that initiates the PGC-1a enzyme. This action
leads to gene expression, specifically genes that revolve around
energy expenditure.GW501516 (also known as GW-501,516, GW1516,
GSK-516) is a PPAR& receptor agonist that was invented in a
collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in
the 1990s, was entered into clinical development as a drug
candidate for metabolic diseases and cardiovascular diseases, and
was abandoned in 2007 because animal testing showed that the drug
caused cancer to develop rapidly in several organs.
In 2007 research was published showing that high doses of GW501516
given to mice dramatically improved their physical performance; the
work was widely discussed in popular media, and led to a black
market for the drug candidate and to its abuse by athletes as a
The effects of GW-501516 are fairly significant and may be a
welcomed addition to the stack for a performance athlete. Increased
endurance may be the PPAR-RA's most incredible attribute. Those who
use the medication will find they do not tire out as easily and can
train harder and longer.
The cardiovascular endurance that comes with GW-501516 is so strong
it has been shown to do away with the cardio issues that surround
the popular anabolic steroid Trenbolone. Many who use Trenbolone
report breathing becomes a bit more difficult and that cardio
becomes a more arduous task. GW-501516 seems to negate this
negative effect when using Tren.
The effects of GW-501516 also help tremendously with fat loss. If
nothing else, you're able to perform your cardio more intensely and
longer. Further, it doesn't carry any catabolic effect that is
associated with many thermogenics or fat burners, meaning muscle
loss due to use is of no concern. More importantly, GW-501516 has
been shown to increase nutrient efficiency. Simply put, you make
better use of the nutrients you're consuming. Those who use the
compound will find increased levels of glucose uptake and fat
The known side effects of GW-501516 primarily surround increasing
the chances of cancer; however, it's not quite that cut and dry.
Studies that showed increased cancer rates in rats used doses of
the PPAR-RA far above and beyond what any human would take.
Further, additional studies have shown GW-501516 decreased existing
cancerous tumors and in effect cured the existing cancer.
The truth behind the relationship with this drug and cancer is
unknown at this time. Because there is a potential relationship
between the medication and cancer, we may never know the truth as
it's unlikely any major pharmacy group will undertake any
Based on its positive attributes, GW-501516 may be one of the
single best products an athlete could buy. However, although not an
anabolic steroid, numerous sporting bodies have already banned it
and it will show up in sports doping tests. But when it comes to
the benefits, endurance and enhancing nutrient efficiency are two
benefits that are hard to beat. It's hard to beat this into the
head of many athletes, recovery, endurance and food itself are the
three most important factors associated with making gains or
improving performance, and GW-501516 does just that.
Although the benefits of GW-501516 are undeniable, we are still
left with the glaring possibility of use-induced cancer. Regardless
of how much muscle you carry or how low your body fat is, cancer is
going to ruin the physique you've built, not to mention your life.
The odds of cancer, from looking at some of the studies that were
done they do appear to be somewhat flawed, while others scream
It is truly hard to say what would happen if you were to try this
drug, but there does appear to be a legitimate risk, and enough of
one to cause a very large pharmaceutical giant to completely give
up on what could have been a highly profitable drug had the cancer
scare not existed.GW501516 (also known as GW-501,516, GW1516,
GSK-516 and Endurobol)is a PPAR receptor.
It activates the same pathways activated through exercise,
including PPAR and AMP-activated protein kinase. It had been
nvestigated as a potential treatment for obesity, diabetes,
dyslipidemia and cardiovascular disease. GW501516 has a synergistic
effect when combined with AICAR: the combination has been shown to
significantly increase exercise endurance in animal studies more
than either compound.
An experimental drug meant to control lipids and increase the level
of HDL, or good cholesterol, in the bloodstream. A cell-permeable,
thiazolyl compound that acts as a potent, high affinity, PPARδ
Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does
not exibit any activity against other nuclear or non-nuclear
receptors. Reported to increase cholesterol efflux and ABAC1
expression in macrophages, fibroblasts, and intestinal cells.
There are two main uses with GW-501516.
The first and most common use is that of increased endurance. GW
has been banned for professional athletes due to the unfair
advantage it provides to endurance athletes. Anyone want a drastic
increase in endurance will find that GW truly shines in this
aspect. It takes effect very quickly and the results can be
staggering. A common dose of 10 mg day will provide a significant
increase in endurance.
Cardarine is used by athletes competing in many different sports.
For instance, endurance athletes may increase exercise endurance by
stacking this PPAR with the AMP analog drug AICAR, or run cardarine
solo. As a result, they will have a greater ability to reach higher
RPM's during their runs without hitting the maximum heart rate.
This will allow the runner/cyclist/swimmer to cheat their maximum
heart rates and go longer without getting winded, making this stack
an incredible weapon to use in endurance sports.
Actually, from personal experience I can tell that cardarine can
knock over 30-45 seconds off a 5K time if used leading up to a
The second common usage with GW is that of fat loss. Many users
turn to GW as it has shown to melt off fat while still being
non-catabolic. You will find that you can still hold on to some
muscle as you are losing fat. It helps when you are running it in
conjunction with SARMS Ostarine and S4, to hold on to as much
muscle as possible. A dosage of 10 mg a day will provide good
amounts of fat loss, but an increase to 20 mg a day will provide
much more in this area.
Cardarine was primarily developed to treat obesity, diabetes, lipid
strain, and heart health problems. As a matter of fact, those who
run blood work will notice that cardarine will magically aid with
lipid strain, and their cholesterol levels will improve
Regarding the bodybuilders, cardarine can benefit them in two ways
1. Its ability to burn fat
2. Its ability to help the athlete have harder and longer workouts,
without getting winded.
GW-501516 is taken orally . The most common dosing range for this
PPAR-RA is 10-15mg per day for 8 weeks. However , some reports
state the medication needs to be used for 12 weeks for optimal
results , with 20mg per day being well tolerated by most
Not to say that there are none , but in the last 20 years no side
effects have been seen by anyone studying the drug .
GW501516 has not only been tested in healthy subjects , but also
those with simulated "real life" habits (such as drinking alcoho l,
stimulant narcotics , and the use of tobacco products) . It is
uncertain if there are long term ramifications , but no research
has been published stating otherwise .
This is what makes Cardarine so incredibly popular and usable over
long periods of time . In certain studies , there have even been
signs showing the reversal of diabetes , obesity, Dyslipidemia and
many other diseases.
The half life of cardarine is 20-24 hours. This means that once a
day dose is totally fine. Some athletes like to use all the 20 mg
an hour before their workout session, and others will split the
dose in half in the AM and PM.
It is best to squirt the liquid into your mouth, swallow, and then
chase down with some juice or water.
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|CJC-1295 with DAC||2mg|
|CJC-1295 without DAC||2mg|
|pentadecapeptide BPC 157||2mg|
|Ostarine (MK-2866)||CAS: 841205-47-8|
|Cardarine (GW-501516)||CAS: 317318-70-0|
|Andarine (S4)||CAS: 401900-40-1|
|Ligandrol (LGD-4033)||CAS: 1165910-22-4|
|Ibutamoren (MK-677)||CAS: 159752-10-0|
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