99% DMSA / 2,3-Dimercaptosuccinic Acid / Succimer Powder CAS
1. 2,3-Dimercaptosuccinic Acid Quick detail:
Dimercaptosuccinic acid (DMSA), also called succimer, is the organosulfur compound with the
This colorless solid contains two carboxylic acid and two thiol
groups, the latter being responsible for its mildly unpleasant
odour. It occurs in two diastereomers, meso and the chiral dl
forms. The meso isomer is used as achelating agent. The acid is
most often used as a treatment for heavy metal toxicity, and is a
water soluble and non-toxic substance.
Succimer: 2,3-Dimercaptosuccinic acid; DMSA;succimer
CAS #: 304-55-2
Appearance: White Crystalline Powder, which is soluble in alkaline solution,
slightly soluble in methanol and insoluble in water.
Application: Intermediate for sodium dimecaptosuccinate(DMS), an antidote for
Packing: 1kg/aluminum tin; 25kg/carton barrel.
Storage: Protect from humidity; keep in a dry, cool, and shady place.
Shelf Life: 2 years
2. 2,3-Dimercaptosuccinic Acid Description:
DMSA/Dimercaptosuccinic Acid, is the organosulfur compound with the
CO2H. This colorless solid contains two carboxylic acid and two
thiol groups, the latter being responsible
for its mildly unpleasant odour. It occurs in two diastereomers,
meso and the chiral dl forms. The meso
isomer is used as achelating agent. The acid is most often used as
a treatment for heavy metal toxicity,
and is a water soluble and non-toxic substance.
3. 2,3-Dimercaptosuccinic Acid Application:
DMSA/Dimercaptosuccinic Acid is indicated for the treatment of lead
poisoning in children with blood
level measured above 45 µg/dL. The use of DMSA is not approved for
prophylactic/prevention of lead
poisoning in anticipation of exposure in known lead contaminated
environments. Its elimination
half-life is 2.5-3.5 h. DMSA can cross the blood–brain barrier of
mice, but not that of humans, limiting its use to extracting heavy
metals from parts of the
body other than the central nervous system.
Another application for DMSA is for provocation of tissue heavy
metals in anticipation of a urine test. This
is sometimes called a "challenge" or "provoked" heavy metals test.
DMSA is used to help mobilize heavy
metals stored in body tissues (and therefore not typically present
in the circulation) and increase the
excretion of heavy metals in the urine. In a study by Howard
Frumkin et al., this sort of test was shown to
not reliably provide an indication of past chronic mercury
exposure, something it was often used for. A
2004 study by GP Archbold, et al. called the results of a DMSA
challenge test "misleading" for the
purposes of diagnosing mercury toxicity. Moreover, DMSA share the
limitation of extracellular
distribution, which makes it unable to cross the cell membrane and
chelate heavy metals from
The relative activities of a series of novel monoalkyl esters of
meso-2,3-dimercaptosuccinic acid (DMSA) have been examined as
agents for the mobilization of cadmium, lead
and arsenic owing to the ability of these monoesters to cross cell
membranes. The monoesters were
found to be more effective than the parent compound DMSA.
4. 2,3-Dimercaptosuccinic Acid Certificate of Analysis:
|Odor & Taste||Characteristic||Characteristic|
|Loss on drying||≤1.0%||0.26%|
(Total bacterial Count)≤3,000
(Total Mold & Yeast Count)≤300
|Residue on ignition (SO4 )||≤0.1%||0.05%|
|Conclusion||Compiles with above standard|
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