Gamma-Butyrolactone Pharmaceutical Raw Materials transparent liquid
1,4- Butyrolactone GBL CAS 96-48-0 For Bodybuilding
Gamma Butyrolactone Quick Detail:
Product name: GBL Gamma Butyrolactone
Chemical Name: gamma-Butyrolactone
Molecular Formula: C4H6O2
Formula Weight: 86.09
Chemical Properties:colourless oily liquid
General Description:Clear colorless oily liquid with a pleasant
Air & Water Reactions:Hygroscopic,Soluble in water.
Packing: According to the request.
Usage :pharmaceutical raw materials, the hormone
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GBL is a lactone. It is hydrolyzed under basic conditions, for
example in a sodium hydroxide solution into sodium gamma -
hydroxybutyrate, the sodium salt of gamma - hydroxybutyric acid.
Under acidic conditions it forms an equilibrium mixture of both
compounds. These compounds then may go on to form a polymer. When
treated with a non - nucleophilic base, like lithium
diisopropylamide, GBL can become an alpha - carbon nucleophile. The
related compound caprolactone can be used to make a polyester in
GBL is not active in its own right; its mechanism of action stems
from its identity as a prodrug of GHB. The hypnotic effect of GHB
is enhanced by combination with alcohol. A 2003 rat study showed
that GBL in combination with ethanol showed a potentiated hypnotic
effect, as the sleep-timing measure was longer than both of the
individual components combined
GBL is rapidly converted into GHB by paraoxonase ( lactonase )
enzymes, found in the blood. Animals which lack these enzymes
exhibit no effect from GBL. GBL is more lipophilic ( fat soluble )
than GHB, and so is absorbed faster and has higher bioavailability.
Because of these pharmacokinetic differences, GBL tends to be more
potent and faster - acting than GHB, but has a shorter duration;
whereas the related compound 1,4- butanediol ( 1,4- B ) tends to be
slightly less potent, slower to take effect but longer - acting
Colorless transparent liquid
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Addictiveness and dependence
Frequent use of GHB / GBL, even when taken long-term and in
moderate doses, does not appear to cause significant physical
dependency in the majority of its users. In many people, quitting
or temporarily abstaining from use of the drugs is achieved with
minimal or no difficulty. However, when consumed in excessive
amounts with a high frequency of dosing, physical and psychological
dependence can develop. Management of GBL dependence involves
considering the person's age, comorbidity and the pharmacological
pathways of GBL.
There are some reports of GHB/GBL users adopting a '24/7' dosing
regime. This is where the user has become tolerant to the effects
of the drug, increasing the dosage and frequency of dosage simply
to avoid withdrawal symptoms.
For those users who do report withdrawal symptoms upon quitting the
use of GHB / GBL, symptoms seem to depend on the dosage and the
length of time the drug was used. Light to moderate users often
experience insomnia and sleep - related problems, whereas heavy,
prolonged use can cause severe withdrawal symptoms similar to
Benzodiazepine withdrawal syndrome.
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