Pharmaceutical Fat Loss Powder Rimonabant Acomplia Safest Female
Keywords: Rimonaban, Acomplia, Rimonaban Pills, Rimonaban Dosage,
Rimonaban Powder, Rimonaban USA, Rimonaban UK.
Rimonabant Basic Information:
|Chemical Properties||White to off white powder|
|Usage||Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM
and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.|
In a 2006 (2 year) study reported in JAMA, "Compared with the
placebo group, the 20 mg of rimonabant group produced greater mean
(SEM) reductions in weight (-6.3 kg vs -1.6 [0.2] kg; P<.001),
waist circumference (-6.1 [0.2] cm vs -2.5 ] cm; P<.001), and
level of triglycerides (percentage change, -5.3 vs 7.9 ; P<.001)
and a greater increase in level of high-density lipoprotein
cholesterol (percentage change, 12.6 vs 5.4 ; P<.001)."
2) Smoking cessation
Rimonabant may also be found to be effective in assisting some
smokers to quit smoking. Sanofi is currently conducting studies to
determine the possible value of rimonabant in smoking-cessation
therapy. The Studies with Rimonabant and Tobacco Use (STRATUS)
program involves more than 6,000 subjects.
Stratus is designed to explore two smoking-related therapies:
first, to use rimonabant directly to aid in smoking cessation;
second, to help prevent weight gain in former smokers. Initial
results apparently suggest rimonabant is effective for both uses.
However, the FDA has explicitly stated to Sanofi that, without
additional studies, rimonabant cannot be approved in the United
States for smoking cessation therapy.
Rimonabant is one of the most recent drugs created for the
treatment of obesity.
This drug acts as a blockade for endocannabinoid receptors found in
the brain and peripheral organs that play an important role on
carbohydrate and fat metabolism. Clinical studies have confirmed
that, when used in combination with a low calorie diet, rimonabant
promotes loss in body weight, loss in abdominal circumference, and
improvements in dyslipidemia.
Rimonabant is also being tested as a potential anti-smoking
treatment since endocannabinoids are related to the pleasurable
effect of nicotine. Thus, rimonabant constitutes a new therapeutic
approach to obesity and cardiovascular risk factors. Studies show
effectiveness in weight loss; however, side effects such as
psychiatric alterations have been reported, including depression
and anxiety. These side effects have led the FDA (Food and Drug
Administration) to not approve this drug in the United States. For
a more complete evaluation on the safety of this drug, additional
studies are in progress.
(1) Rimonabant is a weight loss drug, can significantly reduce
weight, reduce waist circumference and reduce risk factors for
cardiovascular disease, but also can improve blood lipids and
insulin resistance and metabolic syndrome,
(2) Rimonabant effective in assisting some smokers to quit smoking
Rimonabant Adverse Effect:
Data from clinical trials submitted to regulatory authorities
showed that rimonabant caused depressive disorders or mood
alterations in up to 10% of subjects and suicidal ideation in
around 1%, and in Europe it was contraindicated for people with any
psychiatric disorder, including depressed or suicidal people.
Additionally, nausea and upper respiratory tract infections were
very common (occurring in more than 10% of people) adverse effects;
common adverse effects (occurring in between 1% and 10% of people)
included gastroenteritis, anxiety, irritability, insomnia and other sleep disorders, hot
flushes, diarrhea, vomiting, dry or itchy skin, tendonitis, muscle
cramps and spasms, fatigue, flu-like symptoms, and increased risk
The FDA's advisory committee raised concerns that based on animal
data, it appeared that the therapeutic window with regard to CNS toxicity, and specifically seizures was almost
nonexistent; the therapeutic dose and the dose that caused seizures
in animals appeared to be the same.
When the EMA reviewed postmarketing surveillance data, it found that the risk of psychiatric disorders in people
taking rimonabant was doubled.
Rimonabant Delivery and Packing
(1) 100% Custom Pass Guarantee
(2) Professional and Well- trained Packing Team
(3) Prompt delivery, In 24 hours delivery after payment
(4) Packing pictures and tacking code provided within 1-2 days
(5) 24/7 after sale service.
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