Product Name: Procaine HCL
acid diethylaminoethyl ester
Appearance: White crystalline powder
Usage: Inhibitor of sodium channel
The primary use for procaine is as a topical anaesthetic.Procaine HCL is used less frequently today since more effective
(and hypoallergenic) alternatives such as lidocaine (Xylocaine)
exist. Like other local anesthetics (such as mepivacaine, and
prilocaine), procaine is a vasodilator, and is often coadministered
with epinephrine for the purpose of vasoconstriction.
Application of procaine leads to the depression of neuronal
activity. The depression causes the nervous system to become
hypersensitive producing restlessness and shaking, leading to minor
to severe convulsions. Studies on animals have shown the use of
procaine led to the increase of dopamine and serotonin levels in
the brain.Other issues may occur because of varying individual
tolerance to procaine dosage. Nervousness and dizziness can arise
from the excitation of the central nervous system, which may lead
to respiratory failure if overdosed. Procaine may also induce
weakening of the myocardium leading to cardiac arrest.
Procaine HCL can also cause allergic reactions causing the individuals to have
problems with breathing, rashes, and swelling. Allergic reactions
to procaine are usually not in response to procaine itself, but to
its metabolite PABA. About one in 3000 people have an atypical form
of pseudocholinesterase, which does not hydrolyze
ester anesthetics such as procaine, resulting in a prolonged period
of high levels of the anesthetic in the blood and increased
Certificate Of Analysis:
|Specific Rotation||+39°~ +43°||+40.2°|
|Organic Volatile Impurities||Conform||Conform|
|Loss On Drying||≤0.50%||0.27%|
|Residue On Ignition||≤0.10%||0.015%|
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